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Colleges and universities struggling with their aging science facilities face common challenges when they embark on major renovations: compromised infrastructure; mechanical systems that lack the energy efficiency of modern, sustainable designs; and non-compliance with building codes and the Americans with Disabilities Act. In addition, the buildings may be fully or partially occupied, and the budgets are limited. Overcoming these challenges requires careful planning and a well-considered phasing strategy that often includes tackling the major infrastructure improvements up front.

The Molecular Engineering & Sciences Building at the University of Washington accommodates growth in molecular engineering; responds to the evolving interdisciplinary nature of teaching and research; and fits within an area of campus that is home to revitalized facilities as well as traditional campus architecture.

Driven by a spirit of collaboration, Kaleida Health and the University at Buffalo united within a single structure to bring several disciplines—and patients, surgeons, and researchers—together to exchange knowledge and ignite innovation. The 476,000-sf facility achieves this by stacking a translational research building over a clinical vascular institute. The first floors of this 10-story "vertical campus" house the Gates Vascular Institute (GVI), with the Clinical and Translational Research Center (CTRC) occupying the top half of the building.

Australia's Griffith University is nearing completion of the world's first zero-emission teaching and research facility powered entirely by photovoltaic solar energy and stored hydrogen. In addition to being a practical demonstration of innovative energy technologies, the $40 million Sir Samuel Griffith Centre will serve as a campus cornerstone and collaborative social hub that integrates business, engineering, and environmental science disciplines around the core issues of sustainability.

This book is a collection of management experiences, insights, and lessons learned on building and operating high-containment facilities from facility planners, project directors, owners, end users, science program managers, and facility operators who have worked in the high-containment arena for the ten-year period 2002-2012.